Lucia Bronzetti

In May, Bronzetti was awarded a wildcard into the singles qualifying rounds of Italian Open, but failed to advance to the main draw. She and playing partner Nuria Brancaccio were awarded a wildcard into the doubles main draw, but lost in the first round to Coco Gauff and Veronika Kudermetova.

She made her WTA Tour singles main draw debut in July after qualifying for the Ladies Open Lausanne, where she reached the quarterfinals with wins over Tess Sugnaux and eighth seed Anna Blinkova. Her run was ended by top seed and eventual champion Tamara Zidanšek. The following week, she reached her second tour quarterfinal at Palermo with wins over fifth seed Viktoriya Tomova and Grace Min, before losing to Elena-Gabriela Ruse.

In August, Bronzetti entered the qualifiers for the US Open, but failed to advance past the first round. The next month, she reached the second round of the Karlsruhe Open. Bronzetti qualified for the Zavarovalnica Sava Portorož and made it to the quarterfinals with wins over seventh seed Rebecca Peterson and Bernarda Pera. She lost in the last eight to second seed Yulia Putintseva.

Bronzetti qualified for her first Grand Slam at the 2022 Australian Open after defeating Amandine Hesse, Valeria Savinykh, and Nao Hibino in qualifying. She defeated Varvara Gracheva in the first round before losing to world No. 1 and eventual champion Ashleigh Barty in the second.

In March, she made her WTA 1000 main draw debut as a lucky loser in Miami, reaching the fourth round with wins over Ajla Tomljanović and Stefanie Vögele and a walkover from Anna Kalinskaya, before losing to wild card Daria Saville. Following the tournament, she entered the Top 100.

Bronzetti made her main draw debut as a wildcard at the Italian Open, but lost in the first round to Camila Osorio. She reached her first WTA semifinal at the Morocco Open with wins over eighth seed Anna Kalinskaya, Clara Burel, and third seed Nuria Párrizas Díaz, before losing to compatriot and eventual champion Martina Trevisan. She entered the main draws of both the French Open and Wimbledon, but failed to progress past the first round in both, losing to Jelena Ostapenko and Ann Li respectively.

Bronzetti reached her first WTA Tour final in Palermo with wins over Wang Xiyu, Elina Avanesyan, fifth seed Caroline Garciaand Jasmine Paolini, before losing to sixth seed Irina-Camelia Begu in the championship match.

Wins over Lily Miyazaki, Priscilla Hon, Victoria Jiménez Kasintseva and fifth seed Rebecca Peterson saw her make it through to the final at the WTA 125 Vancouver Open where she lost to qualifier Valentini Grammatikopoulou.

Bronzetti won her first WTA Tour title at the Morocco Open in May, with wins over Rebecca Peterson, eighth seed Tatjana Maria, fourth seed Alycia Parks, and second seed Sloane Stephens, before defeating Julia Grabher in the final.

The following month, she reached her third final and first on grass at the Bad Homburg Open with victories over Julia Grabher, fourth seed Mayar Sherif and eighth seed Varvara Gracheva and the withdrawal of world No. 1, Iga Świątek, in the semifinal. Bronzetti lost to Kateřina Siniaková in the final but reached a new career-high ranking of No. 47 on 3 July.

In August, Bronzetti reached the third round of the US Open, defeating 12th seed Barbora Krejčíková and Eva Lys, before losing to Zheng Qinwen.

During the remainder of the season, she made three WTA 250 quarterfinals at the Guangzhou Open where she lost to Greet Minnen, the Ningbo Open where it was Linda Fruhvirtová her halted her progress, and the Jasmin Open where Jasmine Paolini defeated her.

Having come through qualifying, Bronzetti defeated 10th seed Daria Kasatkina in the first round at the Dubai Open in February, before losing her next match to Anastasia Potapova.

The following month at the Indian Wells Open, she recorded wins over Magdalena Fręch and 32nd seed Anhelina Kalinina to reach the third round where she lost to third seed Coco Gauff.

Seeded 4th, Bronzetti failed to defend her Morocco Open title in May, going out in the quarterfinals to eventual champion Peyton Stearns, losing seven games in a row from 5–0 ahead in the deciding set.

In July, Bronzetti won the clay-court WTA 125 Contrexéville Open in France, defeating Mayar Sherif in a final which lasted more than three-and-a-half hours.

Later that month, she represented Italy at the Paris Olympics but suffered first round defeats in both the singles and women's doubles.

At the US Open in August, Bronzetti defeated Lulu Sun to reach the second round where she lost to second seed Aryna Sabalenka.

Seeded seventh, Bronzetti made it through to the semifinals at the Jasmin Open in Monastir, Tunisia, in September, with wins over Dalma Gálfi, Ann Li and qualifier Antonia Ružić, before losing to Rebecca Šramková in the last four.

In October, having lost in the final qualifying round, she gained entry to the Wuhan Open as a lucky loser, going on to defeat Ajla Tomljanović to reach round two, where she lost to Wang Xinyu in three sets. The following week, Bronzetti defeated Cristina Bucșa in the first round at the Japan Open, before losing to qualifier and eventual champion Suzan Lamens. She continued her good Asian swing form by reaching the semifinals at the Guangzhou Open with straight sets wins over fourth seed Elina Avanesyan, Jaqueline Cristian and Wang Xiyu. Bronzetti lost in the last four to qualifier Caroline Dolehide in a deciding set tie-break.

At the Billie Jean King Cup finals, Bronzetti defeated Magda Linette as Italy overcame Poland 2–1 in the semifinals. She then overcame Viktória Hrunčáková in the opening singles match of the final as Italy claimed the title with a win over Slovakia.

In February, Bronzetti overcame wildcard entrant Simona Halep, third seed Peyton Stearns, seventh seed Elisabetta Cocciaretto and fifth seed Kateřina Siniaková to reach the final at the Transylvania Open, which she lost to top seed Anastasia Potapova. As a result, she jumped 16 places in the WTA rankings to world No. 56.