| Date | R | Home v Away | - | |
|---|---|---|---|---|
| 08/19 02:30 | - | Preston Lions U21 v Brunswick City U21 | D | 2-2 |
| 08/12 02:30 | - | Eastern Lions U21 v Preston Lions U21 | W | 1-2 |
| 07/30 02:30 | - | Preston Lions U21 v Bulleen Lions U21 | L | 0-1 |
| 07/21 08:30 | - | Northcote City U21 v Preston Lions U21 | L | 4-1 |
| 07/14 08:15 | - | Preston Lions U21 v Kingston City U21 | D | 1-1 |
| 07/07 08:30 | - | Brunswick Juventus U21 v Preston Lions U21 | W | 1-2 |
| 07/02 02:30 | - | Preston Lions U21 v Langwarrin U21 | D | 0-0 |
| 06/23 08:00 | - | Melbourne City FC U21 v Preston Lions U21 | L | 2-0 |
| 06/16 08:15 | - | Preston Lions U21 v Manningham Utd Blues U21 | L | 0-1 |
| 06/04 01:00 | - | Preston Lions U21 v Dandenong City U21 | D | 1-1 |
| 05/26 08:15 | - | Preston Lions U21 v Werribee City U21 | W | 2-0 |
| 05/19 08:15 | - | Pascoe Vale U21 v Preston Lions U21 | W | 1-4 |
| 05/13 08:00 | - | Brunswick City U21 v Preston Lions U21 | D | 2-2 |
| 05/07 02:30 | - | Preston Lions U21 v Eastern Lions U21 | D | 1-1 |
| 05/01 08:15 | - | Bulleen Lions U21 v Preston Lions U21 | D | 3-3 |
| 04/21 08:15 | - | Preston Lions U21 v Northcote City U21 | W | 4-3 |
| 04/17 08:15 | - | Kingston City U21 v Preston Lions U21 | W | 1-9 |
| 04/09 02:30 | - | Preston Lions U21 v Brunswick Juventus U21 | W | 5-2 |
| 04/01 01:45 | - | Langwarrin U21 v Preston Lions U21 | D | 1-1 |
| 03/05 02:23 | - | Dandenong City U21 v Preston Lions U21 | L | 2-1 |
| 02/25 02:09 | - | Werribee City U21 v Preston Lions U21 | L | 2-1 |