| Date | R | Home v Away | - | |
|---|---|---|---|---|
| 06/06 19:00 | - | Santos Laguna Esports v Toluca Esports | L | 2-3 |
| 06/03 01:00 | - | Santos Laguna Esports v Monarcas Morelia Esports | D | 1-1 |
| 05/30 19:00 | - | Chivas Guadalajara Esports v Santos Laguna Esports | L | 3-1 |
| 05/28 00:00 | - | Queretaro Esports v Santos Laguna Esports | W | 2-3 |
| 05/22 19:30 | - | Santos Laguna Esports v Atletico San Luis Esports | W | 1-0 |
| 05/19 01:30 | - | Santos Laguna Esports v Club America Esports | L | 2-4 |
| 05/15 21:00 | - | Monterrey Esports v Santos Laguna Esports | L | 3-1 |
| 05/13 19:00 | - | Santos Laguna Esports v Necaxa Esports | L | 2-7 |
| 05/09 19:30 | - | Pachuca Esports v Santos Laguna Esports | L | 1-0 |
| 05/06 01:00 | - | Santos Laguna Esports v Atlas Esports | W | 2-1 |
| 05/01 19:00 | - | Juarez FC Esports v Santos Laguna Esports | W | 1-3 |
| 04/27 19:30 | - | Santos Laguna Esports v Tigres UANL Esports | L | 0-4 |
| 04/24 22:15 | - | Puebla Esports v Santos Laguna Esports | W | 0-6 |
| 04/23 01:00 | - | Santos Laguna Esports v Unam Pumas Esports | W | 2-0 |
| 04/18 19:00 | - | Cruz Azul Esports v Santos Laguna Esports | W | 3-4 |
| 04/15 19:00 | - | Santos Laguna Esports v Leon Esports | L | 1-4 |
| 04/13 01:00 | - | Tijuana Esports v Santos Laguna Esports | W | 1-5 |