Tijuana Women

On 5 December 2016, former Liga MX president, Enrique Bonilla, announced the establishment of a women's professional league in Mexico: the Liga MX Femenil. Under this initiative, each club in Liga MX would field a team in the new league. Notoriously, even before the league's announcement, Club Tijuana already boasted a women's professional team, founded in 2014 in collaboration with the late Marbella Ibarra—who was a prominent advocate for women's football in Mexico and a local business owner in Tijuana. The team competed in many regional tournaments within Mexico, and for a time, also in the Women's Premier Soccer League of the United States.

In February 2017, the club announced through its social media channels that it would be forming a women's side. That May, the 2017 Copa MX Femenil was contested between 12 teams, including Xolos Femenil. Las Perrísimas won their group, which also included Necaxa, Santos, and Rayadas. In the final, Tijuana fell 9–1 to Club Pachuca.

On July 29, 2017, led by technical director Andrea Rodebaugh, the Xolas debuted in Apertura 2017 on the road against Club América, a match they lost 1–0. Tijuana had been drawn into Group 2, along with América, Pachuca, Toluca, Pumas, Monarcas, Cruz Azul, and Veracruz.

The first goal by the Xoloitzcuintles in Liga MX Femenil was scored by Evelyn Fernández in week two of the Apertura tournament.

On 18 February 2020, Tijuana midfielder Valentina Oviedo, the Mexican-born daughter of former Colombian international footballer Frankie Oviedo, was called up to the Colombia women's national under-20 team. It marked the first time a player from the Liga MX Femenil was called up to a foreign national team.

On July 8, 2021, Club Tijuana signed their first-ever foreign player, American striker Angelina Hix, from the Chilean club Santiago Morning. Hix had played in both the Copa Libertadores and the UEFA Champions League.

Mexican-American forward Renae Cuéllar is the top scorer in club history, with 76 career goals for the Xolas.

Over the last two seasons, Tijuana has established itself as one of the most competitive clubs in the league, having qualified for two consecutive years to the Liguilla. During Clausura 2023, the club recorded their first ever victory in the Liguilla phase after beating Rayadas 2–0 at home in the first leg of the quarterfinals.