Stadium: Alumni Stadium Round: 1
| NCAAF | 2022/10/01 17:30 | Defiance Yellow Jackets v Hanover | W | 20-37 |
| NCAAF | 2021/10/16 17:30 | Hanover v Defiance Yellow Jackets | W | 51-0 |
| NCAAF | 2019/10/12 17:30 | Defiance Yellow Jackets v Hanover | W | 0-42 |
| NCAAF | 2018/10/13 17:30 | Hanover v Defiance Yellow Jackets | W | 48-7 |
| NCAAF | 2022/11/12 18:30 | Franklin College Grizzlies v Hanover | W | 3-24 |
| NCAAF | 2022/11/05 18:00 | Hanover v Rose Hulman Engineers | L | 17-47 |
| NCAAF | 2022/10/29 17:30 | Anderson Ravens v Hanover | W | 3-62 |
| NCAAF | 2022/10/22 17:30 | Hanover v Mount St. Joseph Lions | L | 29-44 |
| NCAAF | 2022/10/15 17:30 | Manchester Spartans v Hanover | W | 20-51 |
| NCAAF | 2022/10/08 17:30 | Hanover v Bluffton Beavers | W | 63-21 |
| NCAAF | 2022/10/01 17:30 | Defiance Yellow Jackets v Hanover | W | 20-37 |
| NCAAF | 2022/09/17 17:00 | Hanover v Olivet Comets | L | 28-31 |
| NCAAF | 2022/11/12 18:30 | Bluffton Beavers v Defiance Yellow Jackets | W | 14-17 |
| NCAAF | 2022/11/05 17:30 | Defiance Yellow Jackets v Manchester Spartans | W | 24-21 |
| NCAAF | 2022/10/29 17:30 | Rose Hulman Engineers v Defiance Yellow Jackets | L | 76-35 |
| NCAAF | 2022/10/22 17:30 | Defiance Yellow Jackets v Anderson Ravens | W | 32-22 |
| NCAAF | 2022/10/15 17:30 | Franklin College Grizzlies v Defiance Yellow Jackets | L | 48-19 |
| NCAAF | 2022/10/08 17:30 | Mount St. Joseph Lions v Defiance Yellow Jackets | L | 55-35 |
| NCAAF | 2022/10/01 17:30 | Defiance Yellow Jackets v Hanover | L | 20-37 |
| NCAAF | 2022/09/24 16:00 | Alfred State Pioneers v Defiance Yellow Jackets | L | 42-33 |