Stadium: C Ground Round: 5
Home Manager: Dennis Fenech Away Manager: Iro Curmi
| Malta Challenge League | 2022/03/13 13:00 | Luqa SA v Senglea Athletic | W | 0-2 |
| Malta Challenge League | 2021/12/05 18:00 | Senglea Athletic v Luqa SA | W | 1-0 |
| Europe Friendlies | 2023/08/22 16:00 | Hibernians v Senglea Athletic | D | 1-1 |
| Malta Challenge League | 2022/04/04 18:15 | Senglea Athletic v Fgura United | L | 2-3 |
| Malta Challenge League | 2022/03/13 13:00 | Luqa SA v Senglea Athletic | W | 0-2 |
| Malta Challenge League | 2022/03/06 19:00 | Senglea Athletic v Pieta Hotspurs | L | 0-6 |
| Malta Challenge League | 2022/02/26 13:00 | St Andrews v Senglea Athletic | L | 3-2 |
| Malta Challenge League | 2022/02/19 17:00 | Senglea Athletic v Marsa FC | L | 3-5 |
| Malta Challenge League | 2022/02/11 16:00 | Zebbug Rangers FC v Senglea Athletic | L | 4-1 |
| Malta Challenge League | 2022/02/05 17:00 | Senglea Athletic v Qrendi FC | L | 2-3 |
| Malta Challenge League | 2022/04/09 12:00 | Mgarr United v Luqa SA | L | 1-0 |
| Malta Challenge League | 2022/03/13 13:00 | Luqa SA v Senglea Athletic | L | 0-2 |
| Malta Challenge League | 2022/03/05 17:00 | Luqa SA v St Andrews | L | 0-2 |
| Malta Challenge League | 2022/02/26 13:00 | Zebbug Rangers FC v Luqa SA | L | 4-0 |
| Malta Challenge League | 2022/02/18 20:00 | Luqa SA v Swieqi Utd | W | 1-0 |
| Malta Challenge League | 2022/02/13 14:00 | Tarxien Rainbows FC v Luqa SA | L | 3-0 |
| Malta FA Trophy | 2022/02/08 19:30 | Mosta FC v Luqa SA | L | 5-0 |
| Malta Challenge League | 2022/02/05 17:00 | Luqa SA v Fgura United | L | 1-2 |