[17] NY Islanders 2-3 BUF Sabres [22] 2022-09-05 18:30
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Lane Lambert
Head to Head
| NHL | 2022/04/23 16:30 | NY Islanders v BUF Sabres | L | 3-5 |
| NHL | 2022/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-6 |
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | W | 1-4 |
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | L | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | L | 2-4 |
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | W | 2-5 |
Home History
| NHL | 2022/04/29 23:30 | TB Lightning v NY Islanders | L | 6-4 |
| NHL | 2022/04/28 23:00 | WAS Capitals v NY Islanders | W | 1-5 |
| NHL | 2022/04/26 23:00 | NY Islanders v WAS Capitals | W | 4-1 |
| NHL | 2022/04/24 17:00 | CAR Hurricanes v NY Islanders | L | 5-2 |
| NHL | 2022/04/23 16:30 | NY Islanders v BUF Sabres | L | 3-5 |
| NHL | 2022/04/21 23:30 | NY Rangers v NY Islanders | L | 6-3 |
| NHL | 2022/04/19 23:30 | FLA Panthers v NY Islanders | L | 3-2 |
| NHL | 2022/04/17 23:30 | NY Islanders v TOR Maple Leafs | L | 2-4 |
Away History
| NHL | 2022/04/29 23:00 | CHI Blackhawks v BUF Sabres | W | 2-3 |
| NHL | 2022/04/28 23:00 | BUF Sabres v BOS Bruins | L | 0-5 |
| NHL | 2022/04/23 16:30 | NY Islanders v BUF Sabres | W | 3-5 |
| NHL | 2022/04/21 23:00 | BUF Sabres v NJ Devils | W | 5-2 |
| NHL | 2022/04/17 21:00 | BUF Sabres v PHI Flyers | W | 5-3 |
| NHL | 2022/04/16 23:00 | PHI Flyers v BUF Sabres | W | 3-4 |
| NHL | 2022/04/14 23:00 | STL Blues v BUF Sabres | L | 6-2 |
| NHL | 2022/04/12 23:00 | BUF Sabres v TOR Maple Leafs | W | 5-2 |
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