Head to Head
| NFL Preseason | 2021/08/21 17:00 | BUF Bills v CHI Bears | W | 41-15 |
| NFL | 2018/11/04 18:00 | CHI Bears v BUF Bills | L | 41-9 |
| NFL Preseason | 2018/08/31 00:00 | BUF Bills v CHI Bears | W | 28-27 |
| NFL | 2014/09/07 17:00 | CHI Bears v BUF Bills | W | 20-23 |
Home History
| NFL | 2022/01/23 23:30 | BUF Bills v KC Chiefs | L | 36-42 |
| NFL | 2022/01/16 01:15 | NE Patriots v BUF Bills | W | 17-47 |
| NFL | 2022/01/09 21:25 | NY Jets v BUF Bills | W | 10-27 |
| NFL | 2022/01/02 18:00 | ATL Falcons v BUF Bills | W | 15-29 |
| NFL | 2021/12/26 18:00 | BUF Bills v NE Patriots | W | 33-21 |
| NFL | 2021/12/19 18:00 | CAR Panthers v BUF Bills | W | 14-31 |
| NFL | 2021/12/12 21:25 | BUF Bills v TB Buccaneers | L | 27-33 |
| NFL | 2021/12/07 01:15 | NE Patriots v BUF Bills | L | 14-10 |
Away History
| NFL | 2022/01/09 18:00 | CHI Bears v MIN Vikings | L | 17-31 |
| NFL | 2022/01/02 18:00 | NY Giants v CHI Bears | W | 3-29 |
| NFL | 2021/12/26 21:05 | CHI Bears v SEA Seahawks | W | 25-24 |
| NFL | 2021/12/21 01:15 | MIN Vikings v CHI Bears | L | 17-9 |
| NFL | 2021/12/13 01:20 | CHI Bears v GB Packers | L | 30-45 |
| NFL | 2021/12/05 18:00 | ARZ Cardinals v CHI Bears | L | 33-22 |
| NFL | 2021/11/25 17:30 | CHI Bears v DET Lions | W | 16-14 |
| NFL | 2021/11/21 18:00 | BAL Ravens v CHI Bears | L | 16-13 |
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