Stadium: First Bank and Trust Arena Round: 1
Home Manager: Anthony Bozzella Away Manager: Aaron Johnston
| WNCAAB | 2021/12/21 17:00 | Wagner Women v Seton Hall (W) | W | 62-70 |
| WNCAAB | 2021/12/19 17:00 | Marquette (W) v Seton Hall (W) | W | 57-69 |
| WNCAAB | 2021/12/14 23:00 | Central Florida Women v Seton Hall (W) | L | 68-56 |
| WNCAAB | 2021/12/11 17:00 | Seton Hall (W) v Princeton (W) | W | 70-60 |
| WNCAAB | 2021/12/05 19:00 | Seton Hall (W) v St. John's (W) | L | 75-88 |
| WNCAAB | 2021/12/04 00:00 | Connecticut (W) v Seton Hall (W) | L | 74-49 |
| WNCAAB | 2021/11/26 21:00 | Toledo Women v Seton Hall (W) | W | 63-68 |
| WNCAAB | 2021/11/25 21:00 | Seton Hall (W) v USC (W) | L | 65-79 |
| WNCAAB | 2021/12/22 23:00 | South Dakota State (W) v Oral Roberts (W) | W | 71-51 |
| WNCAAB | 2021/12/21 00:00 | South Dakota State (W) v UMKC Women | W | 85-78 |
| WNCAAB | 2021/12/16 01:00 | South Dakota State (W) v Dakota Wesleyan Tigers Women | W | 90-43 |
| WNCAAB | 2021/12/11 20:00 | Kansas State (W) v South Dakota State (W) | L | 79-73 |
| WNCAAB | 2021/12/07 01:00 | Missouri State Women v South Dakota State (W) | L | 55-52 |
| WNCAAB | 2021/12/04 20:00 | South Dakota State (W) v Northern Iowa (W) | L | 50-59 |
| WNCAAB | 2021/11/27 16:00 | UCLA (W) v South Dakota State (W) | W | 66-76 |
| WNCAAB | 2021/11/26 16:00 | South Dakota State (W) v Massachusetts (W) | L | 63-81 |