[15] PHI Flyers 3-4 BUF Sabres [6] 2022-02-08 01:00
Stadium: KeyBank Center
Home Manager: Mike Yeo Away Manager: Don Granato
Head to Head
| NHL | 2022/01/22 18:00 | PHI Flyers v BUF Sabres | L | 3-6 |
| NHL | 2021/04/11 18:00 | BUF Sabres v PHI Flyers | L | 5-3 |
| NHL | 2021/03/31 23:30 | PHI Flyers v BUF Sabres | L | 1-6 |
| NHL | 2021/03/29 23:00 | PHI Flyers v BUF Sabres | W | 4-3 |
| NHL | 2021/03/10 00:00 | BUF Sabres v PHI Flyers | W | 4-5 |
| NHL | 2021/02/28 20:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/02/27 18:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/01/20 00:00 | BUF Sabres v PHI Flyers | W | 0-3 |
Home History
| NHL | 2022/02/02 00:00 | WPG Jets v PHI Flyers | W | 1-3 |
| NHL | 2022/01/29 18:00 | LA Kings v PHI Flyers | W | 3-4 |
| NHL | 2022/01/26 00:30 | PHI Flyers v NY Islanders | L | 3-4 |
| NHL | 2022/01/25 00:00 | DAL Stars v PHI Flyers | L | 3-1 |
| NHL | 2022/01/22 18:00 | PHI Flyers v BUF Sabres | L | 3-6 |
| NHL | 2022/01/21 00:00 | CLB Blue Jackets v PHI Flyers | L | 2-1 |
| NHL | 2022/01/19 00:00 | NY Islanders v PHI Flyers | L | 4-3 |
| NHL | 2022/01/18 00:30 | PHI Flyers v NY Islanders | L | 1-4 |
Away History
| NHL | 2022/02/02 03:00 | BUF Sabres v VGS Golden Knights | L | 2-5 |
| NHL | 2022/01/31 01:00 | BUF Sabres v COL Avalanche | L | 1-4 |
| NHL | 2022/01/30 02:00 | BUF Sabres v ARZ Coyotes | W | 3-1 |
| NHL | 2022/01/26 00:00 | BUF Sabres v OTT Senators | L | 0-5 |
| NHL | 2022/01/22 18:00 | PHI Flyers v BUF Sabres | W | 3-6 |
| NHL | 2022/01/21 00:00 | DAL Stars v BUF Sabres | L | 5-4 |
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | W | 3-1 |
| NHL | 2022/01/17 18:00 | DET Red Wings v BUF Sabres | L | 3-2 |
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