Stadium: Murphy Center
Home Manager: Cindy Stein Away Manager: Rick Insell
| WNCAAB | 2021/03/12 17:00 | Southern Illinois (W) v Missouri State Women | L | 59-70 |
| WNCAAB | 2021/03/11 22:30 | Indiana State Women v Southern Illinois (W) | W | 89-90 |
| WNCAAB | 2021/03/06 22:00 | Southern Illinois (W) v Northern Iowa (W) | L | 41-64 |
| WNCAAB | 2021/03/05 22:00 | Southern Illinois (W) v Northern Iowa (W) | L | 56-67 |
| WNCAAB | 2021/02/28 22:00 | Valparaiso Women v Southern Illinois (W) | L | 70-63 |
| WNCAAB | 2021/02/27 22:00 | Valparaiso Women v Southern Illinois (W) | L | 75-64 |
| WNCAAB | 2021/02/25 00:00 | Missouri State Women v Southern Illinois (W) | L | 67-55 |
| WNCAAB | 2021/02/20 21:00 | Indiana State Women v Southern Illinois (W) | W | 52-76 |
| WNCAAB | 2021/03/21 18:00 | Middle Tennessee (W) v Tennessee (W) | L | 62-87 |
| WNCAAB | 2021/03/13 23:00 | Middle Tennessee (W) v Rice (W) | W | 68-65 |
| WNCAAB | 2021/03/13 02:30 | UTEP (W) v Middle Tennessee (W) | W | 58-74 |
| WNCAAB | 2021/03/11 20:00 | Louisiana Tech Women v Middle Tennessee (W) | W | 71-77 |
| WNCAAB | 2021/03/06 00:00 | Marshall (W) v Middle Tennessee (W) | W | 54-61 |
| WNCAAB | 2021/03/05 00:00 | Marshall (W) v Middle Tennessee (W) | L | 72-49 |
| WNCAAB | 2021/02/27 22:00 | Middle Tennessee (W) v Old Dominion (W) | W | 74-70 |
| WNCAAB | 2021/02/27 00:00 | Old Dominion (W) v Middle Tennessee (W) | L | 74-57 |