[5] TB Lightning 1-5 BUF Sabres [2] 2021-09-22 05:00
Stadium: KeyBank Center
Home Manager: Jon Cooper Away Manager: Don Granato
Head to Head
| NHL | 2020/01/01 00:00 | TB Lightning v BUF Sabres | W | 6-4 |
| NHL | 2019/11/26 00:00 | BUF Sabres v TB Lightning | W | 2-5 |
| NHL | 2019/11/09 18:00 | BUF Sabres v TB Lightning | W | 3-5 |
| NHL | 2019/11/08 19:00 | TB Lightning v BUF Sabres | W | 3-2 |
| NHL | 2019/02/22 00:30 | BUF Sabres v TB Lightning | W | 1-2 |
| NHL | 2019/01/13 00:00 | TB Lightning v BUF Sabres | W | 5-3 |
| NHL | 2018/11/30 00:30 | BUF Sabres v TB Lightning | W | 4-5 |
| NHL | 2018/11/14 00:30 | TB Lightning v BUF Sabres | L | 1-2 |
Home History
| NHL | 2021/07/08 00:00 | MTL Canadiens v TB Lightning | W | 0-1 |
| NHL | 2021/07/06 00:00 | TB Lightning v MTL Canadiens | L | 2-3 |
| NHL | 2021/07/03 00:00 | TB Lightning v MTL Canadiens | W | 6-3 |
| NHL | 2021/07/01 00:00 | MTL Canadiens v TB Lightning | W | 1-3 |
| NHL | 2021/06/29 00:00 | MTL Canadiens v TB Lightning | W | 1-5 |
| NHL | 2021/06/26 00:00 | NY Islanders v TB Lightning | W | 0-1 |
| NHL | 2021/06/24 00:00 | TB Lightning v NY Islanders | L | 2-3 |
| NHL | 2021/06/22 00:00 | NY Islanders v TB Lightning | W | 0-8 |
Away History
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | L | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | L | 4-8 |
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | W | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | W | 2-4 |
| NHL | 2021/05/01 17:00 | BUF Sabres v BOS Bruins | L | 2-6 |
| NHL | 2021/04/29 23:00 | BUF Sabres v BOS Bruins | L | 2-5 |
| NHL | 2021/04/27 23:00 | BUF Sabres v NY Rangers | L | 1-3 |
| NHL | 2021/04/25 22:00 | BUF Sabres v NY Rangers | L | 3-6 |
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