Stadium: London Round: 12
Referee: JP Doyle Home Manager: Mark Mapletoft Away Manager: Alan Dickens
| Prem Rugby | 2017/09/30 14:00 | Northampton v Harlequins | L | 30-22 |
| Prem Rugby | 2017/05/06 15:00 | Northampton v Harlequins | L | 22-20 |
| Prem Rugby | 2016/10/08 14:00 | Harlequins v Northampton | W | 20-9 |
| Prem Rugby | 2016/03/27 14:15 | Northampton v Harlequins | L | 29-23 |
| Prem Rugby | 2016/02/06 14:00 | Harlequins v Northampton | L | 23-27 |
| Prem Rugby | 2015/02/27 19:45 | Northampton v Harlequins | L | 17-13 |
| Prem Rugby | 2014/12/27 16:30 | Harlequins v Northampton | L | 25-30 |
| European Rugby Challenge Cup | 2014/04/25 19:00 | Northampton v Harlequins | L | 18-10 |
| European Rugby Champions Cup | 2017/10/14 16:30 | Harlequins v La Rochelle | L | 27-34 |
| Prem Rugby | 2017/10/06 18:45 | Harlequins v Sale Sharks | W | 42-26 |
| Prem Rugby | 2017/09/30 14:00 | Northampton v Harlequins | L | 30-22 |
| Prem Rugby | 2017/09/23 14:00 | Harlequins v Leicester | L | 28-31 |
| Prem Rugby | 2017/09/17 14:00 | Wasps v Harlequins | W | 21-24 |
| Premiership Rugby Shield | 2017/09/11 18:30 | London Irish A v Harlequins | W | 7-45 |
| Prem Rugby | 2017/09/09 14:00 | Harlequins v Gloucester | W | 28-17 |
| Premiership Rugby Shield | 2017/09/04 16:30 | Harlequins v Exeter Braves | L | 9-20 |
| European Rugby Champions Cup | 2017/10/21 14:15 | Clermont v Northampton | L | 24-7 |
| European Rugby Champions Cup | 2017/10/15 16:30 | Northampton v Saracens | L | 13-57 |
| Prem Rugby | 2017/10/07 14:00 | Gloucester v Northampton | L | 29-24 |
| Prem Rugby | 2017/09/30 14:00 | Northampton v Harlequins | W | 30-22 |
| Prem Rugby | 2017/09/24 14:00 | London Irish v Northampton | W | 25-40 |
| Prem Rugby | 2017/09/15 18:45 | Northampton v Bath | W | 24-6 |
| Prem Rugby | 2017/09/09 15:30 | Northampton v Leicester | W | 24-11 |
| Prem Rugby | 2017/09/02 13:00 | Saracens v Northampton | L | 55-24 |