Stadium: Lumen Field Round: 1
Home Manager: Kyle Shanahan Away Manager: Mike Macdonald
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 7 | 0 | 7 | 0 | 10 | 17 |
| 0 | 10 | 10 | 0 | 3 | 13 |
| SF 49ers | SEA Seahawks |
| Lineup | |
|---|---|
| 78 - OL - Ben Bartch | Byron Murphy - DT - 91 |
| 92 - DT - Jordan Elliott | Charles Cross - OL - 67 |
| 68 - OL - Colton McKivitz | Mike Morris - DE - 94 |
| 77 - OL - Dominick Puni | Zach Charbonnet - Right back - 26 |
| 7 - K - Thomas Morstead | Anthony Bradford - Guard - 75 |
| 48 - Left back - Tatum Bethune | Derick Hall - OLB - 58 |
| 61 - OL - Matt Hennessy | Nehemiah Pritchett - Center back - 28 |
| 94 - DE - Yetur Gross-Matos | Kenneth Walker III - Right back - 9 |
| 75 - OL - Connor Colby | Drake Thomas - Left back - 42 |
| 99 - DT - CJ West | Jalen Sundell - Center - 61 |
| 95 - DT - Alfred Collins | Josh Jobe - DB - 29 |
| 25 - Center back - Jason Pinnock | Tariq Woolen - Center back - 27 |
| 2 - DB - Deommodore Lenoir | Chris Stoll - - 41 |
| 46 - LS - Jon Weeks | Abraham Lucas - OL - 72 |
| 85 - TE - George Kittle | George Holani - Right back - 36 |
| 64 - OL - Jake Brendel | AJ Barner - TE - 88 |
| 98 - DE - Mykel Williams | Jaxon Smith-Njigba - WR - 11 |
| 71 - OL - Trent Williams | Devon Witherspoon - Center back - 21 |
| 20 - DB - Upton Stout | Derion Kendrick - Center back - 1 |
| 23 - Right back - Christian McCaffrey | Nick Emmanwori - SAF - 3 |
| 44 - FB - Kyle Juszczyk | Quinton Bohanna - DT - 92 |
| 36 - SAF - Marques Sigle | Chazz Surratt - Left back - 44 |
| 14 - WR - Russell Gage | Ernest Jones - Left back - 13 |
| 15 - WR - Jauan Jennings | Robbie Ouzts - FB - 40 |
| - DB - Renardo Green | Elijah Arroyo - TE - 18 |
| 4 - K - Jake Moody | Tyrice Knight - Left back - 48 |
| 74 - OL - Spencer Burford | Cody White - WR - 82 |
| 26 - DB - Chase Lucas | Josh Jones - OL - 74 |
| 31 - Right back - Isaac Guerendo | Grey Zabel - Center - 76 |
| 13 - QB - Brock Purdy | Tory Horton - WR - 15 |
| 57 - Left back - Luke Gifford | Brady Russell - TE - 38 |
| 93 - DL - Kalia Davis | Coby Bryant - Center back - 8 |
| 3 - Right back - Brian Robinson | Eric Saubert - TE - 81 |
| 89 - TE - Luke Farrell | Michael Dickson - Pivot - 4 |
| 53 - Left back - Dee Winters | DeMarcus Lawrence - DE - |
| 28 - Center back - Darrell Luter Jr. | Jarran Reed - DL - 90 |
| 33 - Center back - Siran Neal | Leonard Williams - DE - 99 |
| 27 - SAF - Ji'Ayir Brown | Cooper Kupp - WR - 10 |
| 59 - OLB - Curtis Robinson | Sam Darnold - QB - 14 |
| 9 - WR - Skyy Moore | Julian Love - Center back - 20 |
| 91 - DT - Sam Okuayinonu | Jalen Milroe - QB - 6 |
| 54 - Left back - Fred Warner | Jason Myers - K - 5 |
| 47 - Left back - Bryce Huff | Boye Mafe - DL - 53 |
| 83 - WR - Marquez Valdes-Scantling | Ty Okada - SS - 39 |
| 1 - WR - Ricky Pearsall | - |
| 97 - DL - Nick Bosa | - |
| 88 - TE - Jake Tonges | - |
| Substitutes | |