Stadium: Raymond James Stadium Round: 6
Home Manager: Kyle Shanahan Away Manager: Todd Bowles
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 3 | 13 | 16 | 3 | 0 | 19 |
| 7 | 13 | 20 | 7 | 3 | 30 |
| SF 49ers | TB Buccaneers |
| Lineup | |
|---|---|
| 36 - SAF - Marques Sigle | Chris Braswell - Left back - 43 |
| 92 - DT - Jordan Elliott | Logan Hall - DL - 90 |
| 28 - Center back - Darrell Luter Jr. | Devin Culp - TE - 82 |
| 6 - DB - Malik Mustapha | Antoine Winfield - SAF - 31 |
| 77 - OL - Dominick Puni | Christian Izien - SAF - 29 |
| 62 - OL - Austen Pleasants | Kaevon Merriweather - SAF - 26 |
| 98 - DE - Mykel Williams | Payne Durham - TE - 87 |
| 44 - FB - Kyle Juszczyk | Ryan Miller - TE - 81 |
| 20 - DB - Upton Stout | Josh Hayes - DB - 32 |
| 75 - OL - Connor Colby | Owen Wright - Right back - 49 |
| 25 - Center back - Jason Pinnock | Tristan Wirfs - OL - 78 |
| 2 - DB - Deommodore Lenoir | Cade Otton - TE - 88 |
| 95 - DT - Alfred Collins | Charlie Heck - OT - 77 |
| 68 - OL - Colton McKivitz | Evan Deckers - - 86 |
| 61 - OL - Matt Hennessy | Elijah Klein - OL - 79 |
| 65 - OL - Drew Moss | Luke Haggard - OL - 72 |
| 56 - Left back - Trevis Gipson | Sean Tucker - Right back - 44 |
| 99 - DT - CJ West | Elijah Roberts - DL - 95 |
| 27 - SAF - Ji'Ayir Brown | Graham Barton - Center - 62 |
| 18 - K - Eddy Pineiro | Sirvocea Dennis - Left back - 8 |
| 89 - TE - Luke Farrell | John Bullock - OLB - 57 |
| 83 - WR - Marquez Valdes-Scantling | Chase McLaughlin - K - 4 |
| 47 - Left back - Bryce Huff | Elijah Simmons - DL - 92 |
| 54 - Left back - Fred Warner | Tykee Smith - DB - 23 |
| 59 - OLB - Curtis Robinson | Sebastian Castro - SAF - 24 |
| 33 - Center back - Siran Neal | Markees Watts - DE - 58 |
| 84 - WR - Kendrick Bourne | Ben Bredeson - OL - 68 |
| 23 - Right back - Christian McCaffrey | Kindle Vildor - Center back - 22 |
| 5 - WR - Demarcus Robinson | C.J. Brewer - DT - 52 |
| 64 - OL - Jake Brendel | Haason Reddick - DL - 5 |
| 46 - LS - Jon Weeks | Dan Feeney - OL - 65 |
| 71 - OL - Trent Williams | Rachaad White - Right back - 1 |
| 15 - WR - Jauan Jennings | Sterling Shepard - WR - 17 |
| 26 - DB - Chase Lucas | Jacob Parrish - Center back - 25 |
| 9 - WR - Skyy Moore | Riley Dixon - Pivot - 9 |
| 91 - DT - Sam Okuayinonu | Deion Jones - Left back - 45 |
| 48 - Left back - Tatum Bethune | Kameron Johnson - WR - 19 |
| 53 - Left back - Dee Winters | Lavonte David - Left back - 54 |
| - DB - Renardo Green | Tez Johnson - WR - 15 |
| 88 - TE - Jake Tonges | Emeka Egbuka - WR - 2 |
| 4 - QB - Adrian Martinez | YaYa Diaby - OLB - |
| 31 - Right back - Isaac Guerendo | Anthony Nelson - DE - 98 |
| 82 - FB - Brayden Willis | Vita Vea - DL - 50 |
| 3 - Right back - Brian Robinson | Greg Gaines - DL - 96 |
| 10 - QB - Mac Jones | Baker Mayfield - QB - 6 |
| 93 - DL - Kalia Davis | Ben Chukwuma - OL - 70 |
| 57 - Left back - Luke Gifford | Jamel Dean - DB - 35 |
| 7 - K - Thomas Morstead | - |
| Substitutes | |