Stadium: Winthrop Coliseum
Home Manager: Jason Williams Away Manager: Semeka Randall Lay
| WNCAAB | 2022/02/09 23:00 | Winthrop (W) v USC Upstate (W) | W | 47-59 |
| WNCAAB | 2022/02/09 00:00 | USC Upstate (W) v Winthrop (W) | W | 73-43 |
| WNCAAB | 2020/12/18 23:00 | Winthrop (W) v USC Upstate (W) | W | 49-56 |
| WNCAAB | 2020/12/17 23:00 | USC Upstate (W) v Winthrop (W) | L | 54-59 |
| WNCAAB | 2020/03/10 23:00 | Winthrop (W) v USC Upstate (W) | W | 57-60 |
| WNCAAB | 2020/03/07 19:00 | USC Upstate (W) v Winthrop (W) | W | 66-59 |
| WNCAAB | 2020/01/09 23:00 | USC Upstate (W) v Winthrop (W) | L | 38-52 |
| WNCAAB | 2019/02/26 23:00 | Winthrop (W) v USC Upstate (W) | W | 49-58 |
| WNCAAB | 2022/11/23 22:00 | USC Upstate (W) v UNC Greensboro Women | L | 48-54 |
| WNCAAB | 2022/11/18 22:00 | Western Carolina Women v USC Upstate (W) | L | 58-48 |
| WNCAAB | 2022/11/15 00:00 | USC Upstate (W) v Virginia Tech Women | L | 24-79 |
| WNCAAB | 2022/11/11 00:00 | USC Upstate (W) v West Virginia (W) | L | 31-81 |
| WNCAAB | 2022/11/07 22:00 | Southern Wesleyan Women v USC Upstate (W) | W | 51-69 |
| WNCAAB | 2022/03/04 01:00 | UNC Asheville Women v USC Upstate (W) | L | 62-57 |
| WNCAAB | 2022/02/26 18:00 | USC Upstate (W) v North Carolina A&T (W) | W | 74-63 |
| WNCAAB | 2022/02/23 23:00 | Longwood (W) v USC Upstate (W) | L | 71-66 |
| WNCAAB | 2022/11/23 22:00 | Winthrop (W) v St. Andrews Women | W | 60-29 |
| WNCAAB | 2022/11/21 23:30 | Winthrop (W) v Georgia State (W) | L | 45-68 |
| WNCAAB | 2022/11/17 15:00 | Winthrop (W) v West Virginia (W) | L | 48-70 |
| WNCAAB | 2022/11/13 19:00 | Coppin State (W) v Winthrop (W) | L | 78-49 |
| WNCAAB | 2022/11/11 00:00 | Winthrop (W) v Western Carolina Women | L | 47-48 |
| WNCAAB | 2022/11/07 23:00 | Winthrop (W) v Central Florida Women | L | 32-72 |
| WNCAAB | 2022/03/01 17:00 | Presbyterian (W) v Winthrop (W) | L | 65-60 |
| WNCAAB | 2022/02/26 19:00 | Winthrop (W) v Gardner Webb Women | L | 51-80 |