[20] FIVE 1-3 OTT Senators [24] 2022-12-02 04:00
Stadium: Canadian Tire Centre
Home Manager: Away Manager: Don Granato
Head to Head
| NHL | 2022/11/17 00:00 | BUF Sabres v OTT Senators | L | 1-4 |
| NHL | 2022/10/13 23:00 | OTT Senators v BUF Sabres | W | 1-4 |
| NHL | 2022/02/18 00:00 | OTT Senators v BUF Sabres | L | 3-1 |
| NHL | 2022/01/26 00:00 | BUF Sabres v OTT Senators | L | 0-5 |
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | W | 3-1 |
| NHL | 2020/02/19 00:30 | BUF Sabres v OTT Senators | L | 4-7 |
| NHL | 2020/01/29 00:00 | OTT Senators v BUF Sabres | L | 5-2 |
| NHL | 2019/12/24 00:30 | BUF Sabres v OTT Senators | L | 1-3 |
Home History
| NHL | 2022/12/02 00:00 | COL Avalanche v BUF Sabres | L | 6-4 |
| NHL | 2022/12/01 00:00 | BUF Sabres v DET Red Wings | W | 5-4 |
| NHL | 2022/11/29 00:00 | TB Lightning v BUF Sabres | L | 6-5 |
| NHL | 2022/11/26 01:00 | NJ Devils v BUF Sabres | L | 3-1 |
| NHL | 2022/11/24 00:00 | STL Blues v BUF Sabres | W | 2-6 |
| NHL | 2022/11/23 00:00 | BUF Sabres v MTL Canadiens | W | 7-2 |
| NHL | 2022/11/20 00:00 | BUF Sabres v TOR Maple Leafs | L | 2-5 |
| NHL | 2022/11/17 00:00 | BUF Sabres v OTT Senators | L | 1-4 |
Away History
| NHL | 2022/12/01 00:00 | NY Rangers v OTT Senators | L | 3-1 |
| NHL | 2022/11/28 03:30 | OTT Senators v LA Kings | W | 3-2 |
| NHL | 2022/11/25 20:00 | OTT Senators v ANA Ducks | W | 5-1 |
| NHL | 2022/11/24 03:00 | OTT Senators v VGS Golden Knights | L | 1-4 |
| NHL | 2022/11/22 03:30 | OTT Senators v SJ Sharks | L | 1-5 |
| NHL | 2022/11/19 18:00 | NJ Devils v OTT Senators | L | 5-1 |
| NHL | 2022/11/17 00:00 | BUF Sabres v OTT Senators | W | 1-4 |
| NHL | 2022/11/14 22:30 | NY Islanders v OTT Senators | L | 4-2 |
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