[7] Stefanos Tsitsipas 7-6,5-7,6-3 John Isner [50] 2022-06-17 21:00
Stadium: P&G Center Court Round: 27 Ground: Hardcourt outdoor
Head to Head
| French Open | 2021/06/04 19:00 | Stefanos Tsitsipas v John Isner | 5-7,6-3,7-6,6-1 |
| ATP Acapulco | 2021/03/18 04:00 | Stefanos Tsitsipas v John Isner | 6-3,6-2 |
| ATP New York | 2020/08/25 21:30 | John Isner v Stefanos Tsitsipas | 6-7,6-7 |
| ATP Beijing | 2019/10/04 08:50 | John Isner v Stefanos Tsitsipas | 6-7,3-6 |
| Wimbledon | 2018/07/09 13:40 | John Isner v Stefanos Tsitsipas | 6-4,7-6,7-6 |
| ATP Shanghai | 2017/10/11 12:20 | Stefanos Tsitsipas v John Isner | 6-7,6-7 |
Home History
| ATP Halle | 2022/06/15 13:30 | Nick Kyrgios v Stefanos Tsitsipas | 5-7,6-2,6-4 |
| ATP Halle | 2022/06/14 13:55 | Benjamin Bonzi v Stefanos Tsitsipas | 6-7,6-1,3-6 |
| ATP Stuttgart | 2022/06/10 13:05 | Stefanos Tsitsipas v Andy Murray | 6-7,3-6 |
| ATP Stuttgart | 2022/06/09 13:40 | Stefanos Tsitsipas v Dominic Stephan Stricker | 6-3,6-4 |
| French Open | 2022/05/30 12:00 | Holger Rune v Stefanos Tsitsipas | 7-5,3-6,6-3,6-4 |
| French Open | 2022/05/28 14:35 | Mikael Ymer v Stefanos Tsitsipas | 2-6,2-6,1-6 |
| French Open | 2022/05/26 15:25 | Zdenek Kolar v Stefanos Tsitsipas | 3-6,6-7,7-6,6-7 |
| French Open | 2022/05/24 18:45 | Lorenzo Musetti v Stefanos Tsitsipas | 7-5,6-4,2-6,3-6,2-6 |
Away History
| French Open | 2022/05/27 13:40 | John Isner v Bernabe Zapata Miralles | 4-6,6-3,4-6,7-6,3-6 |
| French Open | 2022/05/25 09:00 | John Isner v Gregoire Barrere | 6-4,6-4,3-6,7-6 |
| French Open | 2022/05/22 11:40 | John Isner v Quentin Halys | 7-6,4-6,7-6,7-6 |
| ATP Rome | 2022/05/11 10:50 | Rafael Nadal v John Isner | 6-3,6-1 |
| ATP Rome | 2022/05/10 11:25 | Francisco Cerundolo v John Isner | 4-6,3-6 |
| ATP Madrid | 2022/05/04 12:25 | Cameron Norrie v John Isner | 6-4,6-7,6-4 |
| ATP Madrid | 2022/05/01 13:00 | Filip Krajinovic v John Isner | 6-7,4-6 |
| ATP Houston | 2022/04/10 19:00 | Reilly Opelka v John Isner | 6-3,7-6 |
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