Stadium: Lloyd Noble Center Round: 122
Home Manager: Tory Verdi Away Manager: Niele Ivey
| WNCAAB | 2021/11/09 22:00 | Central Connecticut State Women v Massachusetts (W) | W | 50-87 |
| WNCAAB | 2021/03/22 20:00 | Ohio (W) v Massachusetts (W) | W | 71-95 |
| WNCAAB | 2021/03/20 18:00 | Charlotte Women v Massachusetts (W) | W | 75-81 |
| WNCAAB | 2021/03/20 00:00 | Massachusetts (W) v Villanova Women | L | 51-78 |
| WNCAAB | 2021/03/14 16:00 | Massachusetts (W) v VA Commonwealth Women | L | 69-81 |
| WNCAAB | 2021/03/13 21:00 | Massachusetts (W) v St Louis Women | W | 90-81 |
| WNCAAB | 2021/03/12 22:00 | Massachusetts (W) v Fordham (W) | W | 80-70 |
| WNCAAB | 2021/03/11 22:00 | St Joseph's Women v Massachusetts (W) | W | 69-79 |
| WNCAAB | 2021/11/12 00:00 | Western Illinois Women v Notre Dame (W) | W | 50-76 |
| WNCAAB | 2021/11/10 00:00 | Ohio (W) v Notre Dame (W) | W | 69-105 |
| WNCAAB | 2021/03/05 01:30 | Clemson (W) v Notre Dame (W) | L | 68-63 |
| WNCAAB | 2021/02/28 20:00 | Louisville (W) v Notre Dame (W) | L | 78-61 |
| WNCAAB | 2021/02/26 00:00 | Florida State (W) v Notre Dame (W) | W | 64-72 |
| WNCAAB | 2021/02/23 01:00 | Notre Dame (W) v Pittsburgh (W) | W | 59-48 |
| WNCAAB | 2021/02/07 19:00 | Notre Dame (W) v Louisville (W) | L | 65-71 |
| WNCAAB | 2021/01/31 16:00 | Notre Dame (W) v Syracuse (W) | L | 69-81 |