[26] John Isner 6-7,6-7 Reilly Opelka [23] 2022-01-23 12:00
Stadium: Stadium Round: 28 Ground: Hardcourt indoor
Head to Head
| ATP Atlanta | 2019/07/24 23:00 | John Isner v Reilly Opelka | 6-7,7-6,6-7 |
| ATP New York | 2019/02/17 00:00 | John Isner v Reilly Opelka | 7-6,6-7,6-7 |
| Australian Open | 2019/01/14 02:55 | Reilly Opelka v John Isner | 7-6,7-6,6-7,7-6 |
Home History
| Australian Open | 2022/01/18 03:15 | Maxime Cressy v John Isner | 7-6,7-5,6-7,6-7,6-4 |
| ATP Adelaide 2 | 2022/01/12 04:30 | Thanasi Kokkinakis v John Isner | 6-7,7-6,7-6 |
| ATP Cup | 2022/01/05 23:00 | Daniel Evans v John Isner | 6-4,7-6 |
| ATP Cup | 2022/01/03 23:00 | Jan-Lennard Struff v John Isner | 7-6,4-6,7-5 |
| ATP Cup | 2022/01/01 23:00 | Brayden Schnur v John Isner | 1-6,3-6 |
| Davis Cup | 2021/11/28 19:10 | John Isner v Daniel Elahi Galan | 3-6,6-3,6-7 |
| Davis Cup | 2021/11/26 16:45 | John Isner v Jannik Sinner | 2-6,0-6 |
| ATP Indian Wells | 2021/10/11 03:30 | John Isner v Yoshihito Nishioka | 6-3,6-4 |
Away History
| Australian Open | 2022/01/21 04:30 | Reilly Opelka v Denis Shapovalov | 6-7,6-4,3-6,4-6 |
| Australian Open | 2022/01/19 01:40 | Reilly Opelka v Dominik Koepfer | 6-4,6-3,7-6 |
| Australian Open | 2022/01/17 07:45 | Reilly Opelka v Kevin Anderson | 6-3,6-4,7-6 |
| ATP Sydney | 2022/01/14 05:15 | Reilly Opelka v Andy Murray | 7-6,4-6,4-6 |
| ATP Sydney | 2022/01/13 05:30 | Brandon Nakashima v Reilly Opelka | 6-7,2-6 |
| ATP Sydney | 2022/01/12 03:25 | Jordan Thompson v Reilly Opelka | 3-6,2-6 |
| ATP Melbourne | 2022/01/06 09:20 | Maxime Cressy v Reilly Opelka | 4-6,7-6,7-6 |
| Davis Cup | 2021/11/26 15:00 | Reilly Opelka v Lorenzo Sonego | 3-6,6-7 |
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