[11] NY Islanders 3-6 BUF Sabres [7] 2021-09-25 06:00
Stadium: KeyBank Center
Home Manager: Barry Trotz Away Manager: Don Granato
Head to Head
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | L | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | L | 2-4 |
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | W | 2-3 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | W | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | W | 3-1 |
Home History
| NHL | 2021/06/26 00:00 | NY Islanders v TB Lightning | L | 0-1 |
| NHL | 2021/06/24 00:00 | TB Lightning v NY Islanders | W | 2-3 |
| NHL | 2021/06/22 00:00 | NY Islanders v TB Lightning | L | 0-8 |
| NHL | 2021/06/20 00:00 | TB Lightning v NY Islanders | W | 2-3 |
| NHL | 2021/06/18 00:00 | TB Lightning v NY Islanders | L | 2-1 |
| NHL | 2021/06/16 00:00 | NY Islanders v TB Lightning | L | 2-4 |
| NHL | 2021/06/13 19:00 | NY Islanders v TB Lightning | W | 2-1 |
| NHL | 2021/06/09 23:30 | BOS Bruins v NY Islanders | W | 2-6 |
Away History
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | L | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | L | 4-8 |
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | W | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | W | 2-4 |
| NHL | 2021/05/01 17:00 | BUF Sabres v BOS Bruins | L | 2-6 |
| NHL | 2021/04/29 23:00 | BUF Sabres v BOS Bruins | L | 2-5 |
| NHL | 2021/04/27 23:00 | BUF Sabres v NY Rangers | L | 1-3 |
| NHL | 2021/04/25 22:00 | BUF Sabres v NY Rangers | L | 3-6 |
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