Stadium: Raiford G. Trask Coliseum
Home Manager: Mike McGuire Away Manager: Karen Barefoot
| WNCAAB | 2021/11/24 19:30 | Lees-McRae Women v Radford (W) | W | 39-95 |
| WNCAAB | 2021/11/21 19:00 | Radford (W) v West Virginia (W) | L | 31-83 |
| WNCAAB | 2021/11/20 00:00 | Radford (W) v Lenoir Rhyne Bears Women | W | 75-44 |
| WNCAAB | 2021/11/14 19:00 | Marshall (W) v Radford (W) | L | 68-64 |
| WNCAAB | 2021/11/10 23:00 | Radford (W) v Pittsburgh (W) | L | 63-82 |
| WNCAAB | 2021/02/26 22:00 | Radford (W) v Campbell (W) | L | 50-53 |
| WNCAAB | 2021/02/25 22:00 | Radford (W) v Campbell (W) | W | 74-71 |
| WNCAAB | 2021/02/21 18:00 | Charleston Southern (W) v Radford (W) | W | 67-76 |
| WNCAAB | 2021/11/23 19:00 | UNC Wilmington (W) v Campbell (W) | L | 42-53 |
| WNCAAB | 2021/11/20 19:00 | Coastal Carolina (W) v UNC Wilmington (W) | L | 73-62 |
| WNCAAB | 2021/11/18 23:00 | UNC Wilmington (W) v Maryland (W) | L | 66-108 |
| WNCAAB | 2021/11/14 19:00 | UNC Wilmington (W) v Duke (W) | L | 45-87 |
| WNCAAB | 2021/11/11 00:00 | UNC Wilmington (W) v Mount Olive Women | W | 74-65 |
| WNCAAB | 2021/03/11 19:30 | UNC Wilmington (W) v Delaware (W) | L | 52-70 |
| WNCAAB | 2021/03/10 19:30 | UNC Wilmington (W) v Coll of Charleston (W) | W | 60-47 |
| WNCAAB | 2021/03/05 22:30 | Towson (W) v UNC Wilmington (W) | W | 65-75 |