Stadium: Levi's Stadium Round: 1
Home Manager: Arthur Smith Away Manager: Kyle Shanahan
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 3 | 7 | 10 | 3 | 0 | 13 |
| 3 | 14 | 17 | 14 | 0 | 31 |
| ATL Falcons | SF 49ers |
| Lineup | |
|---|---|
| 47 - - Josh Harris | Ambry Thomas - Center back - 20 |
| 32 - SAF - Jaylinn Hawkins | Ross Dwelley - TE - 82 |
| 95 - DL - Ta'Quon Graham | Trent Sherfield - WR - 81 |
| 70 - OL - Jake Matthews | Fred Warner - Left back - 54 |
| 61 - OL - Matt Hennessy | Demetrius Flannigan-Fowles - SAF - 45 |
| 20 - Center back - Kendall Sheffield | Kentavius Street - DE - 95 |
| 84 - Right back - Cordarrelle Patterson | Daniel Brunskill - TE - 60 |
| 3 - Left back - Mykal Walker | Samson Ebukam - DL - 56 |
| 2 - QB - Matt Ryan | Brian Hill - Right back - 36 |
| 67 - Center - Drew Dalman | George Kittle - TE - 85 |
| 35 - Right back - Avery Williams | D.J. Jones - DT - 93 |
| 48 - Left back - Dorian Etheridge | Jordan Willis - DE - 94 |
| 8 - TE - Kyle Pitts | Taybor Pepper - LS - 46 |
| 77 - OT - Jalen Mayfield | Jake Brendel - OL - 64 |
| 92 - DE - Adetokunbo Ogundeji | Arden Key - Left back - 98 |
| 84 - QB - Feleipe Franks | Marcell Harris - DB - 36 |
| 34 - Center back - Darren Hall | Brandon Aiyuk - WR - 11 |
| 27 - SAF - Richie Grant | Charlie Woerner - TE - 89 |
| 40 - FB - Keith Smith | Jeffery Wilson - Right back - 30 |
| 24 - Center back - A.J. Terrell | Talanoa Hufanga - SAF - 29 |
| 94 - DL - Anthony Rush | River Cracraft - WR - 13 |
| 85 - TE - Lee Smith | Deommodore Lenoir - DB - 2 |
| 54 - MLB - Foyesade Oluokun | Charles Omenihu - DL - 92 |
| 36 - SAF - Shawn Williams | JaMycal Hasty - Right back - 23 |
| 6 - K - Younghoe Koo | Mitch Wishnowsky - Pivot - 18 |
| 6 - DL - Dante Fowler Jr. | Jauan Jennings - WR - 15 |
| 96 - DL - Tyeler Davison | Kevin Givens - DT - 90 |
| 22 - DB - Fabian Moreau | Nick Bosa - DL - 97 |
| 28 - Right back - Mike Davis | Deebo Samuel - WR - 19 |
| 97 - DT - Grady Jarrett | Jarrod Wilson - SAF - |
| 93 - Left back - James Vaughters | Tyrell Adams - Left back - |
| 4 - WR - Tajae Sharpe | Robbie Gould - K - 9 |
| 69 - OL - Jason Spriggs | Jimmy Garoppolo - QB - 10 |
| 45 - Left back - Deion Jones | Josh Norman - Center back - 26 |
| 51 - Left back - Brandon Copeland | Alex Mack - Center - 50 |
| 13 - WR - Christian Blake | Travis Benjamin - WR - 17 |
| 30 - Right back - Qadree Ollison | Arik Armstead - DL - 91 |
| 63 - OL - Chris Lindstrom | K'Waun Williams - DB - 24 |
| 88 - WR - Frank Darby | Laken Tomlinson - OG - 75 |
| 76 - OL - Kaleb McGary | Jaquiski Tartt - SAF - 3 |
| 19 - K - Thomas Morstead | Aaron Banks - OG - 65 |
| 14 - WR - Russell Gage | Tom Compton - OL - 66 |
| 66 - OL - Colby Gossett | Jimmie Ward - SAF - 1 |
| 55 - DL - Steven Means | Dontae Johnson - Center back - 27 |
| 81 - TE - Hayden Hurst | Kyle Juszczyk - FB - 44 |
| 21 - DB - Duron Harmon | Trent Williams - OL - 71 |
| 17 - Right back - Olamide Zaccheaus | - |
| 98 - DT - Mike Pennel | - |
| Substitutes | |